Irf3 mouse
WebNov 1, 2012 · IFN regulatory factor 3 (IRF3) regulates early type I IFNs and other genes involved in innate immunity. We have previously shown that cells undergoing an endoplasmic reticulum (ER) stress response called the unfolded protein response produce synergistically augmented IFN-β when stimulated with pattern recognition receptor … WebImmunogen Synthetic peptide within Human IRF3 aa 50-150. The exact sequence is proprietary. Database link: Q14653 (Peptide available as ab203561) Positive control WB: A549, HeLa, Jurkat, THP-1, Daudi, HepG2 whole cell lysates. Human fetal heart and kidney lysates. Mouse heart and spleen lysates, NIH/3T3 whole cell lysates.
Irf3 mouse
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WebJun 1, 2024 · IRF-3 Antibody (SL-12) is a mouse monoclonal IgG 1 κ IRF-3 antibody, cited in 73 publications, provided at 200 µg/ml raised against recombinant IRF-3 fusion protein … WebOct 15, 2013 · Double-deficient Irf-3(-/-)7(-/-) mice infected with the DENV2 strain S221 possessed 1,000-150,000 fold higher levels of viral RNA than wild-type and single-deficient mice 24 h postinfection (hpi); however, they remained resistant to lethal infection.
WebMar 5, 2024 · (C) Immunoblot analysis of p-TBK1, p-IRF3, and IRF3 in mouse PMs transfected with Ctrl siRNA or Rnf39 siRNA 2 for 48 hours and then infected with VSV for the indicated time periods. ( D ) Luciferase activity analysis of IRF3 promoter activity in HEK293T cells transfected with IRF3 reporter plasmid and the indicated adaptor … WebDuring infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and of a kinase complex that includes IKKε and TBK1 (6,7). IRF-3 is …
WebMar 26, 2015 · Interferon Regulatory Factor 3 (IRF3) is an essential transcription factor for the expression of antiviral genes, including type I IFNs and ISGs. ... Ser398 in human IRF3 … WebFeb 4, 2013 · Red - loading control ab8245 (Mouse anti-GAPDH antibody [6C5]) observed at 37kDa. ab76409 was shown to react with IRF3 in wild-type A549 cells in western blot with loss of signal observed in IRF3 knockout cell line ab267097 (IRF3 knockout cell lysate ab256953). Wild-type and IRF3 knockout A549 cell lysates were subjected to SDS-PAGE.
WebThe IRF3 conditional knockout mouse may be a useful tool to identify cell type-specific functions of this transcription factor. Abstract IFN regulatory factor 3 (IRF3) is a …
how does climate affect food productionWebJan 15, 2024 · IFN regulatory factor 3 (IRF3) is a transcription factor that is activated by multiple pattern-recognition receptors. We demonstrated previously that IRF3 plays a … how does climate affect food securityWebMar 26, 2015 · Interferon Regulatory Factor 3 (IRF3) is an essential transcription factor for the expression of antiviral genes, including type I IFNs and ISGs. ... Ser398 in human IRF3 and Ser388, Ser390 in mouse IRF3) . The known signaling pathways activate IRF3 through its phosphorylation by the protein kinase, TBK1, which in turn is activated by signal ... how does climate affect food supplyWebMar 9, 2024 · Irf3 interferon regulatory factor 3 [ (house mouse)] IRF3 inhibits nuclear translocation of NF-kappaB to prevent viral inflammation. Identification and … how does climate affect landscape developmentWebBuy Irf3, Mouse interferon regulatory factor 3, Real Time PCR Primer Set, item number: VMPS-3157 from RealTimePrimers at Biomol! Primers are provided as a 40 µl solution … how does climate affect styles of dressWebMay 5, 2024 · The nuclear translocation of activated IRF3 leads to the transcriptional upregulation of type I interferons and pro-inflammatory cytokines 2, 19, 20. An essential role for cGAS is its capacity to... photo club at mile hiWebIn select wells, rabbit anti-phospho IRF3 (S386) antibody is added to detect phosphorylated IRF3. In the remaining wells, mouse anti-pan-IRF3 antibody is used to detect pan IRF3. After washing away unbound antibody, HRP-conjugated anti-rabbit IgG or HRP-conjugated anti-mouse IgG is pipetted into the wells. photo club australia