Irf2bp2 cancer

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August undefined, 2024

WebMay 19, 2016 · The IRF2BP2–CDX-1 fusion gene has been reported in mesenchymal chondrosarcoma, 16 and there is one previous report of IRF2BP2–RARA in APL. 10 Yin et al. 10 reported a case of APL with IRF2BP2–RARA that involved exon 2 of IRF2BP2 and intron 2 of RARA, with breakpoints at positions 1687 bp in IRF2BP2 and 41620 bp in RARA. The … WebJul 20, 2015 · IRF2BP2 is a cofactor modulating IRF2 and myocyte enhancer factor 2 (MEF2), transcription factors important for innate immunity and gene expression in macrophages. 8 – 12 Exposure of macrophages to bacterial lipopolysaccharide activates the M1 inflammatory phenotype, whereas exposure to interleukin (IL)-4 favors the M2 anti …

Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML …

WebSep 25, 2015 · IRF2BP2 is required for the expression of the anti-inflammatory transcription factor Krüppel-like factor 2 (KLF2). Restoring KLF2 in IRF2BP2-deficient macrophages … WebJul 31, 2024 · Overall, cases 12 (harboring IRF2BP2-NTRK1 ), 13 ( PPL- NTRK1 ), and 25 ( ETV6-NTRK3) were morphologically similar, composed of lobules of partially fused papillae with scattered glomeruloid... sims 4 shower curtains

Expression of IRF2BP2 in lung cancer - The Human Protein Atlas

WebJul 30, 2024 · The levels of the co-transcriptional regulator IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein-2) decrease with T cell activation and, when ectopically expressed, it reduces T cell proliferation. To further characterize the function of IRF2BP2 in T cell responses in vivo, we generated a conditional transgenic knock-in mouse that … WebApr 8, 2024 · The researchers discovered Richter syndrome-specific somatic driver mutations in genes including IRF2BP2, SRSF1, B2M, DNMT3A, and CCND3. They also found recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which they confirmed in 45 independent Richter syndrome cases and … rc hill used cars

The Tumor Suppressor Interferon Regulatory Factor 2 …

The transcriptional cofactor IRF2BP2 plays a key role in T cell ...

WebJul 29, 2024 · Program of Immunology and Tumor Biology, Brazilian National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil. 2. Division of Signaling and Gene Expression, La … WebSep 20, 2024 · The conserved Hippo pathway regulates organ size, tissue homeostasis, and tumorigenesis. Interferon regulatory factor 2 binding protein 2 (IRF2BP2) was originally … rchin poeWebJul 29, 2024 · Translocations and mutations in the human irf2bp2gene have been observed in various cancers including primary central nervous system lymphoma (Pall & Hamilton, 2008), multiple myeloma (Ni et al.,2012), mesenchymal chondrosarcoma (Nyquist et al.,2012) and acute promyelocytic leukemia (Yin et al.,2015), emphasizing the importance … rchin poe trade

"WebApr 29, 2024 · The IRF2BP2 protein is found in different organisms and has been described as ubiquitously expressed in normal and tumor cells and tissues, indicating a possible role for this transcriptional... " - Irf2bp2 cancer

Irf2bp2 cancer

IRF2BP2 interferon regulatory factor 2 binding protein 2 - NIH Genetic

WebJan 1, 2024 · For example, IRF2BP2 is confirmed to be upregulated in gastric cancer, and its deficiency impedes cell proliferation and epithelial-mesenchymal transition. 42 IRF2BP2 represses liver cancer progression via stabilizing VGLL4 and further enhancing VGLL4’s inhibitory effects on Hippo pathway. 43 In our study, we discovered that IRF2BP2 might … WebJun 15, 2024 · Recently, interferon regulatory protein 2 binding protein 2 ( IRF2BP2) emerged as a new RARA partner and was studied by next-generation RNA-sequencing analysis. IRF2BP2 has also been involved in other solid tumors [ 2, 3, 4 ]. Fig. 1 A Wright-Giemsa staining of abnormal promyelocytes at diagnosis. B Alpha naphthol acetate …

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WebExpression of IRF2BP2 (IRF-2BP2) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... BREAST CANCER CARCINOID CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GLIOMA HEAD AND NECK CANCER LIVER CANCER LUNG CANCER LYMPHOMA. WebNov 22, 2016 · IRF2BP2 is a downstream target of p53 and repressor of the cell cycle regulator NFAT1 (refs 7, 8). IRF2BP2 is fused to CDX1 as a result of the t (1;5) (q42;q32) in mesenchymal chondrosarcoma...

WebApr 25, 2024 · Additionally, IRF2BP2 may be involved in cancer development. Finally, it has been recently reported that IRF2BP2 may play a role in macrophage regulation and lymphocyte activation, highlighting ... WebExpression of IRF2BP2 (IRF-2BP2) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of …

WebIRF2BP2_ENST00000366610 Sequences You can see various sequences for this gene: cDNA (ENST00000366609.3) Protein (IRF2BP2) Transcript and protein aligned … WebJan 22, 2024 · IRF2BP2 is a novel HNF4α co-repressor: Its role in gluconeogenic gene regulation via biochemically labile interaction. Kouketsu T, Monma R, Miyairi Y, …

WebIRF2BP2-NTRK1 Fusion is present in 0.02% of AACR GENIE cases, with sarcoma, NOS, breast invasive ductal carcinoma, gastric adenocarcinoma, lung adenocarcinoma, and pancreatic acinar cell carcinoma having the greatest prevalence [ 4 ]. Top Disease Cases with IRF2BP2-NTRK1 Fusion References 1.

WebMar 17, 2024 · The data show that IRF2BP2 is a novel target gene repressed by the YAP-TEAD transcriptional complex, and exhibits potent antitumor activity by inhibiting YAP activity. The researchers identify that IRF2BP2 interacts with VGLL4 and stabilizes the protein level of VGLL4, which leads to synergistic inhibition toward YAP. rc hinge cutterWebExpression of IRF2BP2 (IRF-2BP2) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... To access cancer specific RNA and … rch in fentanylWebMar 29, 2024 · IRF2BP2 is a novel ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles. IRF2BP2 … sims 4 shower cc maxis matchWebApr 1, 2024 · Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) binds to various RNA transcripts and promotes cancer progression, although little is known regarding its regulation. Here we show IGF2BP2 is a substrate of the deacetylase and tumor suppressor sirtuin 1 (SIRT1) and regulates the expression of the vacuolar ATPase subunit ATP6V1A. sims 4 show dog modWebMay 15, 2024 · Here, we identified a novel clinical variant, IRF2BP2 c.625_665del, from two members of a family with inflammatory conditions and investigated the function of IRF2BP2 and c.625_665del mutation in JAK–STAT pathway activation and inflammatory signaling. The levels of constitutive and cytokine-induced phosphorylation of STATs and total … sims 4 shower reversibleWeb癌症免疫疗法是生物医学界目前最热门的领域之一。近日，发表在《科学》杂志上的一项研究中，科学家们发现了一种参与肿瘤免疫逃逸行为的关键蛋白，它与“赫赫有名”的PD-L1蛋白的表达密切相关。这一名为Cdk5的关键蛋白及其相关信号通路有望成为免疫疗法的新靶点。 rch in ctWebIRF2BP2 is altered in 0.02% of all cancers with sarcoma, NOS, breast invasive ductal carcinoma, gastric adenocarcinoma, lung adenocarcinoma, and pancreatic acinar cell … sims 4 shower and bathtub together