WebHere, we show that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a … WebThus, one of the properties of MAZ, in stabilizing CTCF binding, is distinct from the properties of YY1. The stabilization of enhancer–promoter interactions by YY1 is proposed to involve contact between YY1 proteins bound at those sites and further strengthened by interaction with cohesin ( 45 ).

Loop competition and extrusion model predicts CTCF interaction ... - Nature

WebLike CTCF, YY1 also binds to DNA in a methylation-sensitive manner. YY1 can bind the Peg3 ICR and regulate its parent of origin-dependent expression. Insulator assays with … WebDec 31, 2013 · CTCF and YY1 bind to distinct repetitive elements across primate species with no evidence of lineage-specific expansions. (A) Significant CTCF binding event associations with repeat elements. sonoff s31zb

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WebSep 5, 2012 · The comparison between CTCF and YY1 is shown in Figure S5 in Additional file 1, where it is clear that some YY1 sites have strong repressing effects and where our ubiquitously functional CTCF sites have strong activating effects. We show below that the repressive YY1 sites are distinguished by their location relative to the translational start ... WebMar 9, 2024 · Moreover, motifs for CTCF and YY1 are also more enriched on the located regions than that on the negative regions . These results confirm that the located regions are more likely to contain TFBSs. More examples can be found in S9, S10 and S11 Figs, which has the same observations. Overall, FCNsignal has the capability of classifying and ... WebJun 5, 2015 · Through the whole genome analyses of CTCF-binding sites, many co-localized proteins were identified, including YY1, Oct4, RNA polymerases and TR. 39, 40 … small mouth toothbrush