WebCTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact, its DNA binding sites are enriched at the borders of chromatin domains. Recently, we showed that depletion of CTCF impairs the DNA damage response to ionizing radiation. To investigate the relationship … WebApr 4, 2024 · MRD21; FAP108; CFAP108. Summary. This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins.
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WebWe found only 41 differentially called CTCF-binding peaks out of a total of 31,840 called peaks (Figures 2 A and S2; Table S3). Interestingly, 5 out of these 41 binding peaks that were conserved in CTCF-deleted patients correspond to the TCRAD locus and were lost in CTCF wild-type patients with T-ALL due to TCRD recombination (Figure 2 B). WebSep 27, 2024 · CTCF is a conserved DNA- and RNA-binding protein with roles in genome folding and transcriptional regulation. ... Simply knocking out a gene offers only a rough view of its role in early ... great team ice breakers virtual
Embryogenesis without CTCF in flies and vertebrates - Nature
WebChINN is able to predict CTCF-, RNA polymerase II- and HiC- associated chromatin interactions between open chromatin regions. ChINN was able to identify convergent CTCF motifs, AP-1 transcription family member motifs such as FOS, and other transcription factors such as MYC as being important in predicting chromatin interactions. WebJul 15, 2008 · In contrast, when both CTCF and BORIS are present within the cell, which is the case in tumor (HCT116) and immortalized (A911P/A911M) cell lines, BORIS can bind to unmethylated CTCF DNA-binding sites only when CTCF is displaced. This explains why BORIS preferentially binds to the methylated paternal H19 DMR in the hybrid mouse cells. WebOct 6, 2024 · Cleavage of RAD21 in NBS1 buffer eliminated CTCF–CTCF looping interactions, while cohesin-dependent elevated intra-TAD interactions were reduced by only 40–60% (Fig. 3i). Given that 50% of ... great team ice breakers