Chuan he fto

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August undefined, 2024

WebApr 30, 2013 · FTO, which was identified in several genome-wide-association studies to be associated with obesity and type II diabetes 10, 11, 12, is a member of the non-haem Fe II /α-ketoglutarate...

Chuan He, "RNA methylation in gene expression regulation"

WebAug 17, 2024 · “It [was] really a bold and bizarre idea,” says study author Chuan He, a chemist at the University of Chicago. The human body produces tens of thousands of proteins, and the first one his group... WebFeb 18, 2024 · Chuan He, a professor of chemistry at the University of Chicago and a cofounder of Accent Therapeutics, discovered enzymes that remove methyl groups from RNA and showed that they are linked to … sl pheasant\u0027s

m6A RNA modifications are measured at single-base …

WebMay 11, 2024 · Free and open to the public. Chuan He. The University of Chicago, HHMI/Chemistry, Biochemistry and Molecular Biology. Abstract: Over 100 types of post-transcriptional RNA modifications have been … WebJul 1, 2024 · In 2024, Chuan He’s group employed a dCas13b-FTO editor to demethylate the m 6A of LINE1, resulting in an increased half lifetime of LINE1 and globally increased chromatin accessibility. In terms of physiological relevance, targeting LINE1 by dCas13b-FTO resulted in decreased differentiation capacity and increased cell renewal in mouse … WebNov 21, 2014 · Chuan He, … Yun-Gui Yang Show authors Cell Research 24 , 1403–1419 ( 2014) Cite this article 19k Accesses 668 Citations 18 Altmetric Metrics Abstract The role of Fat Mass and Obesity-associated... slp head and neck cancer

Chuan he fto

UChicago scientists uncover clues to mysterious but …

WebJan 10, 2013 · The discovery of FTO as an RNA demethylase raises questions regarding how general such a process could be and whether m 6 A plays roles in other biological processes. We present here ALKBH5 as another mammalian RNA demethylase that catalyzes the removal of the m 6 A modification on nuclear RNA (mostly mRNA) in vitro … WebMar 25, 2024 · Chuan He, PhD. BME Seminar Series Spring 2024 Thursday, March 25, 2024 at 4-5 pm Tech L361 Host: ... FTO and ALKBH5, which catalyze oxidative demethylation of the most prevalent modifications of mammalian messenger RNA (mRNA) and other nuclear RNA, N6-methyladenosine (m6A). These findings indicate that …

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WebMay 5, 2024 · FTO was the first discovered RNA demethylase that reverses messenger RNA N 6 -methyladenosine (m 6 A) modification. Despite numerous past studies, the … WebChuan He interconnects CUL1, Gene expression, Demethylase, Cyclin-dependent kinase 1 and RNA-binding protein in the investigation of issues within Cell biology. His studies deal with areas such as Regulation of gene expression and Methyltransferase complex as well as Gene expression. His Transcription course of study focuses on Chromatin and N6 ...

WebAug 26, 2024 · Hailing Shi 1, Hailing Shi 2, Jiangbo Wei 2, Jiangbo Wei 1, Chuan He 1, ... Epigenetically, FTO mediated m6A demethylation in the 3’UTR of BNIP3 mRNA and induced its degradation via an YTHDF2 independent mechanism. BNIP3 acts as a tumor suppressor and is negatively correlated with FTO expression in clinical breast cancer … WebJun 4, 2024 · FTO knockdown with siRNA led to increased amounts of m(6)A in mRNA, whereas overexpression of FTO resulted in decreased amounts of m(6)A in human cells. We further show the partial colocalization of FTO with nuclear speckles, which supports the notion that m(6)A in nuclear RNA is a major physiological substrate of FTO.

WebJul 23, 2024 · En este escenario, FTO funciona borrando el ARN de m6A para amortiguar algunas de las señales que le dicen a las plantas que disminuyan la velocidad y reduzcan el crecimiento. Imagínese una carretera con muchos semáforos; si los científicos tapan los semáforos rojos y dejan el verde, más y más coches pueden moverse por la carretera. WebMay 5, 2024 · FTO-mediated LINE1 RNA m 6 A demethylation also plays regulatory roles in shaping chromatin state and gene expression during mouse oocyte and embryonic …

WebOct 17, 2011 · image: Professor Chuan He has led researchers who have identified a dynamic new cellular pathway, represented here in molecular form, in the genetic …

WebMar 14, 2024 · FTO treatment removed a large portion of the m 6 A in isolated ... Ge, Bryan T. Harada, Qing Dai, Jiangbo Wei, Lisheng Zhang, Ziyang Hao, Liangzhi Luo, Huanyu … sl pheasant\u0027s-eyesWebNov 15, 2010 · FTO is a DNA and RNA demethylase that affects body mass index and development through an unknown mechanism 18. Although the RNA-processing function of FTO has been suggested to affect gene... sl philosopher\u0027sWelcome to the He Group! Prof. Chuan He was selected as one of the winners of the 2024 Wolf Prize in Chemistry. UChicago News. Wolf Foundation . Exon architecture controls mRNA m 6 A suppression and gene expression Science 2024, 379, 677-682/ RNA's joints play key role in our gene expression, UChicago scientists find UChicago News slp highest peakWebMar 25, 2014 · α-ketoglutarate-dependent dioxygenases FTO and ALKBH5 are m 6 A demethylases of mRNA (and other types of nuclear RNA) that affect biological processes such as development, energy homeostasis and... slp hearing assessmentWebJul 27, 2024 · In tests, researchers found that by adding a gene that encodes for a protein called FTO both rice and potato plants increased yields by 50%. ... University of Chicago professor Chuan He was one of the leaders of the research team. He’s research focuses on how genes are expressed and ways to regulate those processes. It used to be thought … soho adjustable computer tableWebChuan He Student at University of Minnesota Minneapolis, Minnesota, United States. 3 followers 3 connections soho advisorsWebAug 17, 2024 · “It [was] really a bold and bizarre idea,” says study author Chuan He, a chemist at the University of Chicago. ... Plants do not have an FTO-equivalent protein, … slpher